کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6014694 1185939 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Diurnal variations in depression-like behavior of Wistar and spontaneously hypertensive rats in the kainate model of temporal lobe epilepsy
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Diurnal variations in depression-like behavior of Wistar and spontaneously hypertensive rats in the kainate model of temporal lobe epilepsy
چکیده انگلیسی

The purpose of this study was to explore whether the kainate (KA) model of temporal lobe epilepsy (TLE) can be used as a model of comorbid epilepsy and depression to study diurnal behavioral variations in rats. Development of chronic epilepsy was confirmed by the detection of spontaneous motor seizures (SMS) with video monitoring (24 hours/3-5 months after status epilepticus [SE]). KA-treated spontaneously hypertensive rats (SHRs) exhibited higher seizure frequency than Wistar rats during the light phase in the fourth and fifth months after SE. Although epileptic Wistar rats showed depression-like behavior and reduced anxiety mostly during the light phase, there were no diurnal variations in depression-like patterns in SHRs. Anxiety levels of control and epileptic SHRs were similar. Decreases in serotonin, tryptophan, and dopamine concentrations in the hippocampus were detected in epileptic Wistar rats compared with naive controls. However, monoamine levels of epileptic SHRs were close to those of their controls. Wistar rats and SHRs develop stable depression-like behavior during the chronic epileptic phase with strain-dependent diurnal differences.

Research Highlights► Spontaneously hypertensive rats showed higher seizure frequency. ► Epileptic Wistar rats exhibit depression-like behavior during the light phase. ► Depressive behavior was without diurnal rhythms in epileptic SHRs. ► Epileptic Wistar rats are characterized by decreased hippocampal MA levels. ► Еpileptic hypertensive rats had MA levels close to those of their controls.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 20, Issue 2, February 2011, Pages 277-285
نویسندگان
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