Increased seizure susceptibility induced by prenatal methamphetamine exposure in adult female rats is not affected by early postnatal cross-fostering

►The N-methyl-D-aspartic acid and γ-aminobutyric acid systems are involved in the proconvulsive effect of methamphetamine. ►Cross-fostering does not affect the increase in convulsions in female rats prenatally treated with methamphetamine. ►Both prenatal exposure and postnatal exposure to methamphetamine treatment increase susceptibility to N-methyl-D-aspartic acid-induced seizures.