Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy: Long-term outcomes and predictors of response

► Vagus nerve stimulation therapy successfully contributed to seizure control in 436 patients with treatment-resistant epilepsy. ► Nearly 60% of patients experienced at least 50% reduction in seizure burden at the time of last follow-up. ► Complications were few. ► Vagus nerve stimulation is a safe and efficacious palliative treatment option for patients with treatment-resistant epilepsy.