کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6017111 | 1580158 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subcortical evoked activity and motor enhancement in Parkinson's disease
ترجمه فارسی عنوان
فعالیت های ناشی از فراموشی و افزایش حرکت موتور در بیماری پارکینسون
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Enhancements in motor performance have been demonstrated in response to intense stimuli both in healthy subjects and in the form of 'paradoxical kinesis' in patients with Parkinson's disease. Here we identify a mid-latency evoked potential in local field potential recordings from the region of the subthalamic nucleus, which scales in amplitude with both the intensity of the stimulus delivered and corresponding enhancements in biomechanical measures of maximal handgrips, independent of the dopaminergic state of our subjects with Parkinson's disease. Recordings of a similar evoked potential in the related pedunculopontine nucleus - a key component of the reticular activating system - provide support for this neural signature in the subthalmic nucleus being a novel correlate of ascending arousal, propagated from the reticular activating system to exert an 'energizing' influence on motor circuitry. Future manipulation of this system linking arousal and motor performance may provide a novel approach for the non-dopaminergic enhancement of motor performance in patients with hypokinetic disorders such as Parkinson's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 277, March 2016, Pages 19-26
Journal: Experimental Neurology - Volume 277, March 2016, Pages 19-26
نویسندگان
Anam Anzak, Huiling Tan, Alek Pogosyan, Sadaquate Khan, Shazia Javed, Steven S. Gill, Keyoumars Ashkan, Harith Akram, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, Alexander L. Green, Tipu Aziz, Peter Brown,