کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6017120 | 1580158 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of serum immunoglobulins from patients with complex regional pain syndrome (CRPS) on depolarisation-induced calcium transients in isolated dorsal root ganglion (DRG) neurons
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کلمات کلیدی
FBSBAY K8644nIFCTXPGE2CRPSPBSIgGDRGCAVdorsal root ganglion - گانگلیون ریشه پشتیimmunoglobulin - ایمونوگلوبولینBay - خلیجAuto-immunity - خودکار ایمنیfoetal bovine serum - سرم جنین گاوComplex regional pain syndrome - سندرم درد پیچیده منطقه ایphenylephrine - فنیل آفرینphosphate-buffered saline solution - محلول نمک فسفات بافرSensory neurons - نورونهای حسیNifedipine - نیفدیپینProstaglandin E2 - پروستاگلاندین E2voltage-gated calcium channel - کانال کلسیم با ولتاژCalcium - کلسیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of serum immunoglobulins from patients with complex regional pain syndrome (CRPS) on depolarisation-induced calcium transients in isolated dorsal root ganglion (DRG) neurons Effects of serum immunoglobulins from patients with complex regional pain syndrome (CRPS) on depolarisation-induced calcium transients in isolated dorsal root ganglion (DRG) neurons](/preview/png/6017120.png)
چکیده انگلیسی
Complex regional pain syndrome (CRPS) is thought to have an auto-immune component. One such target recently proposed from the effects of auto-immune IgGs on Ca2 + transients in cardiac myocytes and cell lines is the α1-adrenoceptor. We have tested whether such IgGs exerted comparable effects on nociceptive sensory neurons isolated from rat dorsal root ganglia. Depolarisation-induced [Ca2 +]i transients were generated by applying 30 mM KCl for 2 min and monitored by Fura-2 fluorescence imaging. No IgGs tested (including 3 from CRPS patients) had any significant effect on these [Ca2 +]i transients. However, IgG from one CRPS patient consistently and significantly reduced the K+-induced response of cells that had been pre-incubated for 24 h with a mixture of inflammatory mediators (1 μM histamine, 5-hydroxytryptamine, bradykinin and PGE2). Since this pre-incubation also appeared to induce a comparable inhibitory response to the α1-agonist phenylephrine, this is compatible with the α1-adrenoceptor as a target for CRPS auto-immunity. A mechanism whereby this might enhance pain is suggested.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 277, March 2016, Pages 96-102
Journal: Experimental Neurology - Volume 277, March 2016, Pages 96-102
نویسندگان
Joanne M. Reilly, Backialakshmi Dharmalingam, Stephen J. Marsh, Victoria Thompson, Andreas Goebel, David A. Brown,