کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6017449 | 1580167 | 2015 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regeneration of sensory but not motor axons following visceral nerve injury
ترجمه فارسی عنوان
احیای اکسونهای حسی، اما نه حرکتی پس از آسیب عصب احشایی
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کلمات کلیدی
neurofilament 200dorsal root ganglion/gangliatyrosine hydroxylase.GFRα1PGP 9.5DRGNF200ATF-3nNOSGDNFCGRPNPYInferior hypogastric plexus - التهاب زیر جلدیaxotomy - اگزوتیومisolectin B4 - ایزوکتین B4Nerve regeneration - بازسازی عصبCollateral sprouting - زنجیره تأمینneuronal nitric oxide synthase - سنتاز اکسید نیتریک عصبیPelvic surgery - عمل جراحی لگنGlial cell line-derived neurotrophic factor - فاکتور نوروتروفی مشتق از سلول گلیاییActivating transcription factor-3 - فعال کردن عامل رونویسی 3calcitonin gene-related peptide - پپتید مرتبط با ژن کلسی تونینprotein gene product 9.5 - ژن پروتئین محصول 9.5Pelvic ganglia - گانگلیس لگنNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Following peripheral nerve injury, restoration of function may occur via the regeneration of injured axons or compensatory sprouting of spared axons. Injury to visceral nerves that control urogenital organs is a common consequence of pelvic surgery, however their capacity to reinnervate organs is poorly understood. To determine if and how sensory and motor connections to the bladder are re-established, a novel surgical model of visceral nerve injury was performed unilaterally in adult male Wistar rats. Bladder-projecting motor and sensory neurons in pelvic ganglia and lumbosacral dorsal root ganglia, respectively, were identified and characterised by retrograde tracing and immunofluorescence. Application of tracers ipsi- and contralateral to injury distinguished the projection pathways of new connections in the bladder. In naive animals, the majority of sensory and motor neurons project ipsilaterally to the bladder, while ~Â 20 % project contralaterally and ~Â 5 % bilaterally. Injured axons of motor neurons were unable to regenerate by 4Â weeks after transection. In contrast, by this time many injured sensory neurons regrew axons to reform a substantial plexus within the detrusor and suburothelial tissues. These regeneration responses were also indicated by upregulation of activating transcription factor-3 (ATF-3), which was sustained in motor neurons but transient in sensory bladder-projecting neurons. Axotomy had little or no effect on the survival of bladder-projecting sensory and motor neurons. We also found evidence that uninjured motor and sensory neurons develop additional projections to the denervated bladder tissue and return connectivity, likely by undergoing compensatory growth. In conclusion, our results show that visceral sensory and motor neurons have a different capacity to regenerate axons following axotomy, however in both components of the circuit uninjured bladder neurons spontaneously grow new axon collaterals to replace the lost terminal field within the organ. For a full functional recovery, understanding the environmental and cellular mechanisms that reduce the ability of pelvic ganglion cells to undergo axonal regeneration is needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 266, April 2015, Pages 127-142
Journal: Experimental Neurology - Volume 266, April 2015, Pages 127-142
نویسندگان
Sophie C. Payne, Philip J. Belleville, Janet R. Keast,