کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
601769 879953 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Iron/ethylcellulose (core/shell) nanoplatform loaded with 5-fluorouracil for cancer targeting
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Iron/ethylcellulose (core/shell) nanoplatform loaded with 5-fluorouracil for cancer targeting
چکیده انگلیسی

Even though 5-fluorouracil has been demonstrated to display antitumor activity against a wide variety of cancers, high doses are needed to bring out the required therapeutic activity that could simultaneously lead to severe side effects. We hypothesized that the efficient delivery of 5-fluorouracil to tumors using a magnetic nanoplatform could reduce the dose required to obtain sufficient anticancer response. Thus, we have formulated a 5-fluorouracil-loaded magnetic nanomedicine consisting of a magnetic core (iron) and a biocompatible polymeric shell (ethylcellulose). These core/shell nanoparticles were synthesized by an emulsion solvent evaporation process, and 5-fluorouracil loading was assayed by surface incorporation onto the preformed nanocomposites, and by drug incorporation into the magnetic colloid. The contributions of both the surface and the polymeric network to the overall drug loading were investigated by means of optical absorbance and electrophoretic mobility determinations. 5-Fluorouracil entrapment into the polymeric matrix yielded a higher drug loading and a slower drug release profile as compared with drug adsorption. These preliminary results suggest the potential of this stimuli-sensitive drug carrier for cancer targeting.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 77, Issue 1, 1 May 2010, Pages 111–116
نویسندگان
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