کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6017993 | 1580183 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of aging and sex on stroke induced inflammation across the lifespan
ترجمه فارسی عنوان
اثرات افتراقی پیری و جنس بر التهاب ناشی از سکته مغزی در طول عمر
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کلمات کلیدی
ایسکمی، جریان سیاتومتری، استروژن، سن، ارتباط جنسی، ایمنی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Aging and biological sex are critical determinants of stroke outcome. Post-ischemic inflammatory response strongly contributes to the extent of ischemic brain injury, but how this response changes with age and sex is unknown. We subjected young (5-6Â months), middle aged (14-15Â months) and aged (20-22Â months), C57BL/6 male and female mice to transient middle cerebral artery occlusion (MCAO) and found that a significant age by sex interaction influenced histological stroke outcomes. Acute functional outcomes were worse with aging. Neutrophils, inflammatory macrophages, macrophages, dendritic cells (DCs) and microglia significantly increased in the brain post MCAO. Cycling females had higher Gr1â non-inflammatory macrophages and lower T cells in the brain after stroke and these correlated with serum estradiol levels. Estrogen loss in acyclic aged female mice exacerbated stroke induced splenic contraction. Advanced age increased T cells, DCs and microglia at the site of injury, which may be responsible for the exacerbated behavioral deficits in the aged. We conclude that aging and sex have differential effects on the post stroke inflammatory milieu. Putative immunomodulatory therapies need to account for this heterogeneity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 249, November 2013, Pages 120-131
Journal: Experimental Neurology - Volume 249, November 2013, Pages 120-131
نویسندگان
Bharti Manwani, Fudong Liu, Victoria Scranton, Matthew D. Hammond, Lauren H. Sansing, Louise D. McCullough,