کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6018157 1580184 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Lack of type VI adenylyl cyclase (AC6) leads to abnormal sympathetic tone in neonatal mice
چکیده انگلیسی
Visceral functions are regulated by a basal sympathetic nerve discharge (SND), also known as 'sympathetic tone'. We demonstrate herein that AC6 existed in tyrosine hydroxylase-positive rostral ventrolateral medulla neurons in the brainstem. Adenylyl cyclase (AC) assays showed lower basal and pituitary adenylate cyclase-activating peptide-evoked AC activities in the brainstem of AC6-null mice, indicating that AC6 is a prominent AC isozyme in the brainstem. Furthermore, two independent lines of AC6-null mice exhibited a much higher SND, recorded from splanchnic sympathetic nerves of neonatal brainstem-spinal cord preparations, than wildtype mice. An assay of urine noradrenaline confirmed this observation. Collectively, AC6 plays a critical role in the regulation of sympathetic tone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 248, October 2013, Pages 10-15
نویسندگان
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