کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6018163 1580184 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra
چکیده انگلیسی
The presynaptic protein α-synuclein is central to the pathogenesis of α-synucleinopathies. We show that the presence of endogenous mouse α-synuclein leads to higher number of dopaminergic neurons in the substantia nigra of wild-type C57Bl/6J mice compared with C57Bl/6S mice with a spontaneous deletion of the α-synuclein gene or C57Bl/6J mice with a targeted deletion of the α-synuclein gene. This effect of α-synuclein on dopaminergic neuron occurs during development between E10.5 and E13.5 and persists in adult life supporting the involvement of α-synuclein in the development of a subset of dopaminergic neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 248, October 2013, Pages 541-545
نویسندگان
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