Over-expression of N-type calcium channels in cortical neurons from a mouse model of Amyotrophic Lateral Sclerosis

► Voltage-dependent Ca2 + current density is increased in G93A neurons. ► N-type Ca2 + channels are over expressed in G93A cortical cultures and tissues. ► The net Ca2 + entry during membrane depolarization is higher in G93A neurons. ► Increased N-type Ca2 + channel density induces higher mortality in G93A cultures.