The interaction between the dopaminergic forebrain projections and the medial prefrontal cortex is critical for memory of objects: Implications for Parkinson's disease

► A disconnection method was used to investigate the interaction between the mPFC and the DAergic forebrain pathways. ► The interaction is critical for novel object recognition. ► Temporal order memory was impaired by unilateral 6-OHDA lesions. ► Possible mechanisms underlie cognitive deficits in PD.