Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

► Changes in solubility of phosphorylated α-synuclein in Lewy body disease (LBD) brains ► Increase in phosphorylated α-synuclein enhanced in most severe LBD affected brains ► Increase in phosphorylated α-synuclein shift from cingulate to temporal fractions ► Increase in high molecular weight/ubiquitinated forms of phosphorylated α-synuclein