Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease

► Temporal patterns of deep brain stimulation were evaluated in patients with Parkinson's disease. ► Stimulation patterns differentially improved motor task performance. ► Three non-regular patterns of stimulation outperformed clinical regular stimulation. ► Suppression of beta band power in computational model correlated with pattern efficacy. ► Non-regular patterns of stimulation may improve efficacy of deep brain stimulation.