Redox-active Cu(II)-Aβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner

► Redox-active Cu(II)-Aβ1-40 is more toxic than other biochemical forms of Aβ. ► Cu(II)-Aβ causes formation of hyperphosphorylated tau-containing axonal swellings. ► Cu(II)-Aβ causes production of free radicals and leakage of K+ from neurons.