Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages

► Distinct NE effects on Aβ-induced innate immune response. ► NE reduces Aβ-mediated cytotoxicity and MCP-1 secretion. ► NE synergistically increases Aβ-mediated IL-1β secretion. ► NE actions via β-adrenoceptors and cAMP/PKA pathway.