Reduced striatal acetylcholine efflux in the R6/2 mouse model of Huntington's disease: An examination of the role of altered inhibitory and excitatory mechanisms

► Striatal cholinergic interneurons are spared from degeneration in Huntington's disease. ► Acetylcholine release is reduced in the R6/2 mouse model of HD. ► Cholinergic dysfunction may reflect altered excitatory inputs.