Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy

►Chemotherapy-induced peripheral neuropathy (CIPN) is modeled in the rat. ►CIPN-evoked axonal mitochondrial swelling and vacuolation suggest a bioenergetic deficit. ►Mitochondrial respiration and ATP production is impaired in rats with CIPN. ►Chemotherapy-evoked mitotoxicity is a likely cause of CIPN.