Rac1-regulated dendritic spine remodeling contributes to neuropathic pain after peripheral nerve injury

► Dendritic spines on dorsal horn neurons remodel after peripheral nerve injury ► Dendritic spines change in density, distribution, and shape after nerve injury ► Inhibiting Rac1 activity disrupts nerve injury-induced dendritic spine remodeling ► Disrupting dendritic spine remodeling reduces signs of neuropathic pain