Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats

► We test the therapeutic effects of Niaspan in diabetic rats after stroke. ► T1DM rats exhibit increased BBB leakage, brain hemorrhage, vascular damage and decreased functional outcome. ► Niaspan treatment promoted vascular remodeling and improved functional outcome. ► Ang1/Ang2/Tie2 signaling pathways may contribute to diabetes-induced vascular damage. ► Targeting Angiopoietins/Tie2 may have beneficial effect in diabetes with stroke.