Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex

► The effects of chronic noise exposure on tau phosphorylation in the rat hippocampus and the prefrontal cortex. ► CNE led to long-lasting increases in non-NFT hyperphosphorylated tau. ► NFT-tau occurs after persistence of tau hyperphosphorylation. ► GSK3β and PP2A levels increase in close correspondence with increase in tau hyperphosphorylation.