Targeting C/EBP homologous protein with siRNA attenuates cerebral vasospasm after experimental subarachnoid hemorrhage

► The study uses CHOP siRNA approach to reduce cerebral vasospasm after SAH. ► CHOP elimination suppressed bim, while it upregulated bcl-2 in the in vascular tissues. ► Endothelial apoptosis and narrowing of the basilar artery were reduced with siRNA. ► Amelioration of vasospasm was accompanied by reduced neuronal damage in the hemorrhagic brain.