iTRAQ and multiple reaction monitoring as proteomic tools for biomarker search in cerebrospinal fluid of patients with Parkinson's disease dementia

► Application of a gel-free proteomic technique (iTRAQ) to human cerebrospinal fluid. ► Multiple reaction monitoring as antibody free quantification method for CSF proteins. ► Golgin-160 and Apo B-100 were regulated in Parkinson's disease. ► Tyrosine-kinase-non-receptor-type 13 and Netrin-G1 were regulated in PDD.