Interactions of neurotransmitter systems during postnatal development of the rat hippocampal formation: Effects of cisplatin

► The chemotherapeutic cisplatin induces cytotoxic effects on CNS. ► We examine the changes in the developing CNS during rat postnatal life. ► A single injection of cisplatin impaired the hippocampus formation and maturation. ► The neurotransmitter patterns and morphology are damaged. ► Our model system suggests attention when cisplatin is given during childhood.