Altered ventral striatal activation during reward and punishment processing in premanifest Huntington's disease: A functional magnetic resonance study

► Investigation of the ventral striatum as core region of the human reward system. ► Subjects at risk for Huntington's disease (pre-HD) were investigated. ► Functional deficits in reward and punishment processing in pre-HD subjects. ► Voxel-based morphometry was used to control for brain atrophy in pre-HD subjects.