Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors

►Nicotine reduces EAE severity and delays disease onset. ►Multiple nAChRs mediate nicotinic attenuation of EAE. ►Differential expression of nAChRs by immune cells. ►Nicotine inhibits migration of immune cells into the CNS. ►Nicotinic anti-inflammatory effects on lymphocytes may involve other cell types.