TAT-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice

►The exogenous Ngb fusion protein containing TAT-PTD can be efficaciously transduced into the brain tissue. ►The exogenous Ngb fusion protein containing TAT-PTD protects the brain from ischemic injury. ►The TAT-mediated protein transduction provides a promising tool to deliver neuroprotective agents across the blood-brain barrier.