Morphine decreases early peritoneal innate immunity responses in Swiss-Webster and C57BL6/J mice through the inhibition of mast cell TNF-α release

Morphine was found to inhibit LPS-induced TNF-α but not CCL2 release in the peritoneal cavity. Studies on mast cell deficient and reconstituted mice indicate that resident mast cells mediate selective morphine immunosuppression in the peritoneal cavity.