کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6021581 | 1580641 | 2015 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Rodent models of impulsive-compulsive behaviors in Parkinson's disease: How far have we reached?
ترجمه فارسی عنوان
مدل های جوندگان از رفتارهای تسخیری-اجباری در بیماری پارکینسون: تا چه حد ما رسیده ایم؟
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کلمات کلیدی
IGT6-OHDARGTCPPCPAICBAAV6-HydroxydopamineICSSSNCVTADRTDDSl-DOPA - L-DOPAAdeno-associated viral vectors - بردارهای ویروسی Adeno مرتبطParkinson's disease - بیماری پارکینسونconditioned place preference - ترجیح محل موظف استsubstantia nigra pars compacta - توده سیاه پارس متراکمPositron emission tomography - توموگرافی گسیل پوزیترونIntracranial self-stimulation - خود تحریک داخل قلبDopamine replacement therapy - درمان جایگزین دوپامینDopamine - دوپامینDopamine dysregulation syndrome - سندرم اختلال دوپامینCognition - شناختNon-motor symptoms - علائم غیر حرکتیAnimal models - مدل های حیوانیconditioned place aversion - ناامیدی محل سکونتventral tegmental area - ناحیه تگمنتوم شکمیNeurotoxin - نوروتوکسینIowa Gambling Task - وظیفه قمار آیوواParkinson - پارکینسونPET - پت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
There is increasing awareness that the medications used to treat the motor symptoms of Parkinson's disease (PD) contribute to the development of behavioral addictions, which have been clinically defined as impulsive-compulsive behaviors (ICBs). These features include pathological gambling, compulsive sexual behavior, binge eating, compulsive shopping, excessive hobbyism or punding, and the excessive use of dopaminergic medication. ICBs frequently have devastating effects on the social and occupational function of the affected individuals as well as their families. Although ICBs are an important clinical problem in PD, the number of studies in which these symptoms have been modeled in rodents is still limited. This may depend on uncertainties regarding, on one hand, the pathophysiology of these behaviors and, on the other hand, the experimental paradigms with which similar features can be induced in rodents. To help compose these uncertainties, we will here review the characteristics of ICBs in PD patients and then describe behavioral methods to approximate them in rodents. We will discuss both the challenges and the possibilities of applying these methods to animals with PD-like lesions, and review the recent progress made to this end. We will finally highlight important questions deserving further investigation. Rodent models having both face validity and construct validity to parkinsonian ICBs will be essential to further pathophysiological and therapeutic studies into this important area.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 82, October 2015, Pages 561-573
Journal: Neurobiology of Disease - Volume 82, October 2015, Pages 561-573
نویسندگان
M. Angela Cenci, Veronica Francardo, Sean S. O'Sullivan, Hanna S. Lindgren,