Disruption of the GluR2/GAPDH complex protects against ischemia-induced neuronal damage

► GluR2/GAPDH interaction is enhanced in the hippocampus of rats subjected to global ischemia. ► Disruption of GluR2/GAPDH interaction protects against brain damage from global ischemia in the rat hippocampus. ► Disruption of GluR2/GAPDH interaction blocked the decreased GluR2/GAPDH plasma membrane expression in tMCAo rats. ► Disruption of GluR2/GAPDH interaction protects against brain damage from focal ischemia in the rat. ► Inhibition of GAPDH expression protects brain damage from focal ischemia.