Histone modification mapping in human brain reveals aberrant expression of histone H3 lysine 79 dimethylation in neural tube defects

► We report the histone modifications mapping of fetus brain. ► We compared histone modifications difference between controls and NTDs and found H3K79 dimethylation decreased in NTDs. ► ChIP results showed that H3K79me2 binds to some genes which induce NTDs phenotype after knockout in mice.