ABCA1 influences neuroinflammation and neuronal death

► ABCA1 in the brain is anti-inflammatory. ► ABCA1 affects microglia inflammatory response. ► Neuronal ABCA1 influences astrocyte activation. ► Astrocytic ABCA1 regulates brain apolipoprotein E levels. ► Coordinated ABCA1 activity in multiple cell types in the brain influences neurodegeneration.