Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease

► Human fMRI identified an anatomical pattern of caudate dysfunction linked to disease phenotype in HD. ► Decreased expression levels of WIF-1 and PPP1R7 proteins correlated with human HD-MRI data. ► HD mouse fMRI identified a temporal pattern of striatum abnormality. ► fMRI guided Western blot analysis in mice confirmed that deficiency in PPP1R7 is correlated with phenotype.