Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment

► Scn1a mutant mice had low sociability modeling Dravet syndrome's social behavior. ► The mice showed spatial learning deficit that models learning defect of Dravet. ► The mice were hyperactive in novel environments modeling ADHD of Dravet. ► Nav1.1 haploinsufficiency intrinsically causes sociobehavioral and learning defects.