Lack of CCR5 modifies glial phenotypes and population of the nigral dopaminergic neurons, but not MPTP-induced dopaminergic neurodegeneration

► We examined effects of CCR5 deficiency on the dopamine neuron via MPTP animal model. ► CCR5 deletion led to loss of nigral dopamine neurons and microglial activation. ► Monoamine oxidase B was elevated in astrocytes of CCR5 null mice. ► MPTP neurotoxicity was more severe in CCR5 knockout mice. ► We report importance of cross talk between glia and neurons via CCR5.