An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease

► We examined MAG and Necl4 in nerve biopsies of CMT1A patients and in C22 mice. ► We identified an increase in MAG and decrease of Necl4 in CMT1A and C22 mice. ► Ablating MAG in C22 mice results in separation of axons from their myelin sheath. ► Our data show that MAG is important for axon-glia contact in a model for CMT1A.