Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma

► Gabapentin (GBP) decreases injury-induced astrocytosis and is neuroprotective. ► GBP given following cortical injury inhibits synapse formation and decreases excitatory synaptic activity. ► In vivo GBP treatment reduces evoked epileptiform discharges in slices from injured cortex. ► GBP is a potential antiepileptogenic agent