Extrastriatal dopaminergic abnormalities of DA homeostasis in Parkinson's patients with medication-induced pathological gambling: A [11C] FLB-457 and PET study

► Parkinson patients with problem gambling have reduced midbrain dopamine homoeostasis. ► Parkinson patients with problem gambling have reduced dopamine tone in frontal cortex. ► Midbrain and cortical dopamine homeostasis in PD patients correlates with impulsivity.