The methamphetamine-sensitive circadian oscillator is dysfunctional in a transgenic mouse model of Huntington's disease

► The MASCO is not functional in presymptomatic R6/2 mice. ► MAP induces transient beneficial effects on the rest-activity rhythm of R6/2 mice. ► MAP and L-DOPA co-treatment can partially restore the MASCO in R6/2 mice. ► Catecholaminergic systems are implicated in the MASCO (dys)function.