Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin

► In this study we inactivate the mouse Tsc1 gene in dorsal neural progenitor cells. ► We found increased mTORC1 and decreased mTORC2 signaling in the cerebral cortex. ► Tsc1Emx1-Cre CKO mice have abnormalities in cortical neurons as well as glia. ► Tsc1Emx1-Cre CKO mice are smaller than littermates and die by postnatal day 25. ► Postnatal rapamycin treatment rescues mortality and reverses glial abnormalities.