Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice

► First detection of brain levels of anastrozole after oral administration in mice. ► Anastrozole increased Aβ1-40/42-immunostaining in intact 3xTgAD female mice. ► Anastrozole increased the number of CA1 Aβ1-40/42 positive neurons in female mice. ► Anastrozole reduced the APP/Aβ plaque load in 9 month old female 3xTgAD mice.