Interictal high frequency oscillations in an animal model of infantile spasms

► High frequency oscillations (HFOs) occur most frequently during hypsarrhythmia. ► HFOs are most prominent contralateral to the site of TTX infusion. ► HFOs are commonly recorded synchronously across multiple recording sites. ► Multiunit neuronal firing increases abruptly with HFO generation. ► Similar HFOs and multiunit firing occur at the onset of behavioral spasms.