Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures

► Status epilepticus induces significant acute and transient microglia activation. ► Early-life seizure primes microglia response to later-life seizures. ► Minocycline reduces early-life seizure-induced microglial cell activation. ► Minocycline post-treatment prevents the priming effect of early-life seizures.