Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease

► Alike PD brain, tTG-positive ER granules are present in a PD-mimicking cell model. ► tTG localizes to ER and is activated under PD-related stress conditions in vitro. ► tTG activation post-translationally modifies ER membrane proteins.