Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons

► More efficient adeno-associated viral vector construct. ► Development of behavioural deficit. ► Progressive loss of nigral dopamine neurons. ► Axonal pathology and down-regulation of dopaminergic marker. ► Mimic early and late stages of the human disease.