Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice

►GTRAP3-18 gene deletion increases EAAC1 expression in the plasma membrane. ►Neuronal glutathione level is upregulated in GTRAP3-18-deficient mice. ►The GTRAP3-18-deficient mouse brain shows resistance to oxidative stress. ►GTRAP3-18-deficient mice perform better in motor/spatial learning and memory tests. ►A strategy to inhibit GTRAP3-18 function leads to neuroprotection in vivo.