Angiopoietin/Tie2 pathway mediates type 2 diabetes induced vascular damage after cerebral stroke

► We investigate Angiopoietins/Tie2 in vascular damage in diabetes after stroke. ► Diabetic mice have increased vascular damage in the ischemic brain. ► Ang1/Ang2/Tie2 signaling pathways contribute to diabetes-induced vascular damage. ► Targeting Angiopoietins/Tie2 may have beneficial effect in diabetes with stroke.