Reduced gluconeogenesis and lactate clearance in Huntington's disease

►The rise in blood glucose normally seen after exercise was absent in Huntington's disease patients. ►Similar results were seen in R6/2 mice following intraperitoneal lactate injection. ►Hepatic gluconeogenesis and lactate clearance were reduced in this model. ►Brain oxygen, lactate and glucose metabolism did not differ between patients and controls. ►The exercise test could be applied as a liver function test in HD patients.