The scavenger receptor CD36 contributes to the neurotoxicity of bone marrow-derived monocytes through peroxynitrite production

► OGD elicited cytotoxicity in hippocampal slices is not CD36 dependent. ► Microglia activation induced injury in hippocampal slices is also not CD36 dependent. ► Tissue damage by activated bone marrow-derived macrophages (BMM) is CD36 dependent. ► CD36 gene knockout dampens superoxide production in activated BMM. ► Reduction in peroxynitrite formation in CD36−/− BMM leads to neuroprotection.