Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

► Largest behavioral and molecular characterization of 6-OHDA lesions in mice. ► Number of striatal TH+ cells closely correlates with dyskinesia severity. ► Striatal DA content predicts LID development better than histological DA markers.